The department of Human Anatomy and Physiology of the University of Nairobi is a merger of two departments that is Department of Human Anatomy and Department of Medical Physiology in the year 2021. This has led to a drastic increase of students, members none teaching and teaching staff. It has very well equipped Teaching laboratories, lecture theatres and offices to accommodate learners and staffs. The department teaches over 700 students distributed in 8 undergraduate and 9 postgraduate programs. It has despite enormous challenges retained the traditional dissection mode of instruction and blended it with ‘newer’ teaching methods. There are currently 17 members of teaching staff assisted by over 10 part-time demonstrators and 15 technologists. In the recent times, we have transformed research themes from animal and fossil based to patients, autopsy and cadaver material and restored active publication in applied anatomy and diverse clinical fields. This is happening at a time when most human anatomy departments are suffering major declines in time allocation, staffing levels and research output.